Artikkel
Kas GLP-1 ravimid kaitsevad neerusid? Mida uuringud mõõtsid
Mida semaglutide ja teiste GLP-1 ravimite neerutulemuste uuringud mõõtsid kroonilise neeruhaigusega inimestel ning millised on metaanalüüside järeldused.
Mida GLP-1 uuringud tegelikult näitasid
Ei enne-ja-pärast-fotosid, ei mõjuisikuid. Vaid randomiseeritud uuringud, efekti suurused ja osad, mille turundus välja jätab — igale väitele on lisatud viide PubMedi kirjele.
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GLP-1 ravimid ja põlve osteoartroos: mida uuring näitas
Mida kord nädalas manustatava semaglutide uuring rasvumise ja põlve osteoartroosiga inimestel mõõtis, mida see näitas ja mida see ei tõestanud.
Start here
Each page answers one question and shows its working. If you only read one, read the page on stopping — it is the finding that changes how you should think about the whole class.
Mechanism
How GLP-1 drugs actually work
Slower gastric emptying, hypothalamic satiety signalling, and why "it just makes you eat less" is both true and incomplete.
Drug
Semaglutide: what the trials show
STEP 1 through STEP 5, SELECT, and the head-to-head against tirzepatide.
Drug
Tirzepatide: what the trials show
SURMOUNT-1 and -2, sleep apnoea, heart failure, and the largest weight losses recorded for a drug.
Body composition
How much of the loss is muscle?
Roughly a quarter to a third of the weight lost is lean mass. Whether that matters is a harder question.
Safety
Side effects, ranked by how often they happen
Nausea is near-universal and usually transient. The rare events are rarer than the coverage suggests.
Durability
What happens when you stop
Most of the weight comes back within a year. This is the single most important finding in the field.
Outcomes
Does it protect your heart?
SELECT found a 20% reduction in major cardiovascular events — in a population that was not diabetic.
Other uses
Kidneys, liver, sleep apnoea and addiction
Where the evidence is strong, where it is emerging, and where it is currently just hope.
Pipeline
The oral pills
Oral semaglutide and orforglipron: same class, no needle, slightly smaller effect.
Related reading
Fasting Evidence
Intermittent fasting, time-restricted eating and meal timing, judged on the trial data.
Metabolism Review
Energy expenditure, insulin resistance and metabolic adaptation, without the folklore.
Weight Loss Evidence
Diets, drugs, behaviour and maintenance — ranked by the strength of the evidence behind them.
Sleep Evidence
Sleep, circadian rhythm and the wearables that claim to measure both.
This page was translated automatically from English. The citations and numbers are unchanged. Read the English original if anything reads oddly. Read the English original