Läkemedlen

En sida per läkemedel. Effektstorlekar, studiedesigner och de populationer de mättes i.

Peptide

Semaglutide

STEP 1 to STEP 5, SELECT, and roughly 15% mean weight loss in obesity without diabetes.

Dual agonist

Tirzepatide

SURMOUNT-1 and -2, sleep apnoea and heart failure, and about 21% mean weight loss.

Oral

Oral GLP-1

Oral semaglutide and orforglipron — the same mechanism without the injection.

Relaterad läsning

Fasting Evidence

Intermittent fasting, time-restricted eating and meal timing, judged on the trial data.

Metabolism Review

Energy expenditure, insulin resistance and metabolic adaptation, without the folklore.

Weight Loss Evidence

Diets, drugs, behaviour and maintenance — ranked by the strength of the evidence behind them.

Sleep Evidence

Sleep, circadian rhythm and the wearables that claim to measure both.

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