https://glp1facts.org What the trials actually show about semaglutide, tirzepatide and the rest of the GLP-1 class. en Sun, 09 Aug 2026 00:00:00 GMT https://glp1facts.org/how-glp1-works/ https://glp1facts.org/how-glp1-works/ GLP-1 receptor agonists slow gastric emptying and act on hypothalamic satiety circuits. Here is what the mechanistic trials measured, and what they did not. Sat, 01 Aug 2026 00:00:00 GMT Stéphane Sprauer https://glp1facts.org/semaglutide/ https://glp1facts.org/semaglutide/ STEP 1 to STEP 5, SELECT, and the head-to-head against tirzepatide — semaglutide effect sizes with the trial designs that produced them. Sat, 01 Aug 2026 00:00:00 GMT Stéphane Sprauer https://glp1facts.org/tirzepatide/ https://glp1facts.org/tirzepatide/ SURMOUNT-1 and -2, the sleep apnoea and heart failure trials, and the head-to-head win over semaglutide — tirzepatide evidence with effect sizes. Sat, 01 Aug 2026 00:00:00 GMT Stéphane Sprauer https://glp1facts.org/muscle-loss/ https://glp1facts.org/muscle-loss/ Body-composition data from the semaglutide and tirzepatide trials: how much lean mass is lost, how that compares with dieting, and whether it matters. Sat, 01 Aug 2026 00:00:00 GMT Stéphane Sprauer https://glp1facts.org/side-effects/ https://glp1facts.org/side-effects/ Nausea, vomiting, constipation and the rarer events — GLP-1 side-effect rates from the randomised trials, separated from the anecdotes. Sat, 01 Aug 2026 00:00:00 GMT Stéphane Sprauer https://glp1facts.org/stopping/ https://glp1facts.org/stopping/ Withdrawal data from STEP 1 and STEP 4: how much weight comes back, how fast, and what it means for treating obesity as a chronic condition. Sat, 01 Aug 2026 00:00:00 GMT Stéphane Sprauer https://glp1facts.org/cardiovascular/ https://glp1facts.org/cardiovascular/ SELECT, the diabetes outcome trials and the pooled meta-analyses — what GLP-1 receptor agonists do to cardiovascular events. Sat, 01 Aug 2026 00:00:00 GMT Stéphane Sprauer https://glp1facts.org/beyond-weight-loss/ https://glp1facts.org/beyond-weight-loss/ Where GLP-1 receptor agonists have real evidence outside obesity and diabetes — and where the claims are running well ahead of the trials. Sat, 01 Aug 2026 00:00:00 GMT Stéphane Sprauer https://glp1facts.org/oral-glp1/ https://glp1facts.org/oral-glp1/ Oral semaglutide and the small-molecule agonist orforglipron — trial results, how they compare with injections, and what a pill changes. Sat, 01 Aug 2026 00:00:00 GMT Stéphane Sprauer https://glp1facts.org/drug/semaglutide/ https://glp1facts.org/drug/semaglutide/ GLP-1 receptor agonist. Type 2 diabetes and, at the higher dose, weight management. What the trials show and what they do not. Sun, 09 Aug 2026 00:00:00 GMT Stéphane Sprauer https://glp1facts.org/drug/tirzepatide/ https://glp1facts.org/drug/tirzepatide/ Dual GIP / GLP-1 receptor agonist. Type 2 diabetes and weight management. What the trials show and what they do not. Sun, 09 Aug 2026 00:00:00 GMT Stéphane Sprauer https://glp1facts.org/drug/liraglutide/ https://glp1facts.org/drug/liraglutide/ GLP-1 receptor agonist. Type 2 diabetes and weight management. What the trials show and what they do not. Sun, 09 Aug 2026 00:00:00 GMT Stéphane Sprauer https://glp1facts.org/drug/dulaglutide/ https://glp1facts.org/drug/dulaglutide/ GLP-1 receptor agonist. Type 2 diabetes. What the trials show and what they do not. Sun, 09 Aug 2026 00:00:00 GMT Stéphane Sprauer https://glp1facts.org/drug/oral-semaglutide/ https://glp1facts.org/drug/oral-semaglutide/ GLP-1 receptor agonist, oral. Type 2 diabetes; higher-dose oral formulations for weight management have been trialled. What the trials show and what they do not Sun, 09 Aug 2026 00:00:00 GMT Stéphane Sprauer https://glp1facts.org/drug/compounded-glp1/ https://glp1facts.org/drug/compounded-glp1/ Unapproved compounded preparation. Not approved. Sold through compounding pharmacies and online sellers.. What the trials show and what they do not. Sun, 09 Aug 2026 00:00:00 GMT Stéphane Sprauer https://glp1facts.org/about/ https://glp1facts.org/about/ Who publishes GLP-1 Evidence, how pages are researched, and how the site makes money. Sat, 01 Aug 2026 00:00:00 GMT Stéphane Sprauer https://glp1facts.org/editorial-policy/ https://glp1facts.org/editorial-policy/ How GLP-1 Evidence selects evidence, scores products and handles conflicts of interest. Sat, 01 Aug 2026 00:00:00 GMT Stéphane Sprauer https://glp1facts.org/disclosure/ https://glp1facts.org/disclosure/ Every commercial relationship that could affect what you read on GLP-1 Evidence. Sat, 01 Aug 2026 00:00:00 GMT Stéphane Sprauer https://glp1facts.org/privacy/ https://glp1facts.org/privacy/ What GLP-1 Evidence collects — which is close to nothing. Sat, 01 Aug 2026 00:00:00 GMT Stéphane Sprauer https://glp1facts.org/research/2026-08-08/ https://glp1facts.org/research/2026-08-08/ No newly indexed research matched this site's topics in the week of 8 August 2026. Sat, 01 Aug 2026 00:00:00 GMT Stéphane Sprauer